Chiral Synthesis

We offer custom synthesis of chiral molecules through separation of racemic material as well as modern asymmetric synthesis.

• Asymmetric induction
• Chiral pool
• Organocatalysis
• Enzymatic reactions (reductions, esterases, decarboxylases)
• Single and double stereo-differentiating reactions
• Desymmetrization

Fermentation

We’ve developed significant expertise in fermentation to produce APIs, Intermediates and biocatalysts.

• Expert inhouse biotechnology team
• Close collaboration of biotechnology department with chemistry department
• Approx. 300m² commercial fermentation workshop, from 50L to 23,000L fermenters

Synthetic Biology

Our protein expression platform has established four recombinant expression systems from prokaryotic (E.coli, Bacillus) to eukaryotic (Yeast, Brassica napus（plantcell system）).Capabilities:

• 2,400 m2 biocatalysis labs that can handle 5-10 projects simultaneously
• a large in-house library including 2000+ enzymes from commercially available sources enabling rapid screening

Our integrity synthetic biology platform offers a one-stop solution:

• Contract research of protein/peptide expression
• Peptide development and manufacturing
• API industrial strain development
• Biocatalysis development, replacing chemical process with enzyme technology

Photochemistry

• Photochemistry provides with green, high efficiency, low pollution benefits;
• We are manufacturing APIs in ton scale by using photochemistry technology.

Polymorph and Salt

• Discovery of new polymorph, crystallization process development and optimization.
• Milling and micronization：equipped with different milling device, can meet with different PSD requests.

Oligonucleotide development

• Aurisco has an integrated Oligonucleotides process development and manufacturing platform from preclinical to commercial. We support the development and manufacturing of a variety of oligonucleotide modalities including DNA, RNA, Morpholino oligonucleotide (PMO), and etc.

Analytical services

• IPC and release methods development and validation for small and large molecules
• API and Drug Product release testing ICH stability studies
• Reference standard characterization and qualification
• Potential Genotoxic Impurities (PGI) method development, validation and testing
• Impurity/degradant isolation and structure elucidation
• Oligonucleotide and Peptide analysis
• Physical property characterization
• Microbial testing

Key analytical technologies

• Chromatography: UPLC, HPLC, IC, GC
• Mass spectrometry: LC-MS, LC/MS/MS,GC-MS, UPLC-UV-MS, UHPLC-QToF
• Solid state characterization: XRPD, DSC, TGA , PSD
• Identification: NMR
• General testing: KF, UV-Vis,
• PSD testing: Malvern 2000,3000, Sympack
• Elemental analyzer: ICP-MS